Can lung cancer be genetic?

Verified by Dr. Tejinder Singh, Senior Consultant Medical Oncology, Apollo Cancer Centres, Navi Mumbai.

Lung cancer is the leading cause of cancer death worldwide, claiming over 1.8 million lives annually. While smoking is the most significant risk factor, genetics also play a role. Understanding the interplay between genes and environment can offer valuable insights into prevention and treatment strategies.

Genetics and lung cancer risk

It’s important to understand that most lung cancer cases are not directly caused by inherited genetic mutations. However, approximately 8% of cases have a genetic component, with specific genes increasing an individual’s susceptibility.

• Family history and risk assessment

Individuals with a family history of lung cancer, especially first-degree relatives like parents or siblings, are at an increased risk. If you have concerns about your genetic predisposition, consult a doctor or genetic counselor for a risk assessment.

• Early detection and prevention

While genetics play a role, it’s crucial to remember that environmental factors like smoking still contribute most significantly to lung cancer development. Regardless of your genetic risk, maintaining a healthy lifestyle by avoiding smoking, exercising regularly, and maintaining a healthy weight can significantly reduce your overall risk. Early detection of lung cancer through regular health checkups can help in the long run.

Advances in treatment

Understanding the genetic drivers of lung cancer has led to significant advancements in targeted therapies. These drugs specifically target cancer-causing mutations in genes like EGFR and ALK, offering more effective and personalized treatment options.

While genetics play a role in lung cancer risk, it’s important to remember that they are not the sole determinant. Environmental factors, especially smoking, remain the leading cause. However, understanding the genetic factors allows for personalized risk assessment and tailored treatment strategies, leading to improved outcomes for patients.

Consult our expert, Dr. Tejinder Singh, Senior Consultant Medical Oncology, Apollo Cancer Centres, Navi Mumbai for comprehensive management of lung cancer.

Call 022 6280 6280 for an appointment.