Dr. Seerapani Gopaluni is a UK-trained nephrologist and transplant specialist with over 18 years of experience. A PhD graduate from the University of Cambridge, he has extensive expertise in kidney transplantation, autoimmune kidney diseases, glomerulonephritis, and dialysis care.
He has led multiple international clinical trials and has over 25 publications in leading journals. Dr. Gopaluni is known for combining advanced research with compassionate, evidence-based patient care.
Consultant Nephrologist & Transplant Physician – Citizens Hospital Nov 2020 to Aug 2025
2020
PhD in Auto-immune diseases at University of Cambridge 2015 to 2020
2014
2009 to 2014 – Specialty registrar at Churchill Hospitals, Oxford, UK
2009
2008 to 2009 – Specialty registrar at St James Hospital, Leeds, UK
Special interest
Kidney transplantation
ABO and HLA-incompatible kidney transplantation
Paired exchange transplantation
IgA Nephropathy
Complement-mediated glomerulopathies - aHUS
Lupus & Vasculitis
Glomerulonephritis
Diabetic kidney disease
Chronic kidney disease
Acute kidney injury
Haemodialysis
Peritoneal dialysis
Renal biopsies
Dialysis line insertion
Memberships
Indian Society of Transplantion
Indian Society of Nephrology
Federation of Royal College of Physician
Awards & Achievements
Dr APJ Abdul Kalam Health & Medical Excellence Award – 2024
Received grant for £2 Million to conduct a clinical trial called BIOVAS by NIHR - 2019
Received grant for £45,000 by Vasculitis UK Organization to conduct a clinical study - 2017
Received scholarship of £250,000 through Experimental Medicine Training Initiative fellowship for PhD at University of Cambridge - 2016
Received Distinction in the Anatomy / ENT/ Ophthalmology in the University Examination at NTR University of Health Sciences
Research & Publications
01
M McClure, S Gopaluni et al, A randomised study of rituximab and belimumabsequential therapy in PR3 ANCAassociated vasculitis (COMBIVAS): design of thestudy protocol. DOI: 10.21203/rs.3.rs-2138639/v1, March 2023.
02
S Gopaluni, R Smith, D Jayne et al, Alemtuzumab for refractory primary systemicvasculitis—a randomised controlled dose ranging clinical trial of efficacy and safety(ALEVIATE), April 2022, Arthritis Research & Therapy 24(1), DOI:10.1186/s13075-022-02761-6
03
J Tieu, R Smith, S Gopaluni, et al. Rituximab Associated Hypogammaglobulinemia inAutoimmune Disease, May 2021, Frontiers in Immunology 12, DOI:10.3389/fimmu.2021.671503
04
T Helper Cell Dysfunction in ANCA Associated Vasculitis, Dr S Gopaluni, PhDThesis – University of Cambridge, March 2021
05
McClure, M. E., Zhu, Y., Smith, R. M., Gopaluni, S., Tieu, J., Pope, T., … Jones, R.B. (2021). Long-term maintenance rituximab for ANCA-associated vasculitis: relapseand infection prediction models. Rheumatology, 60(3), 1491–1501.https://doi.org/10.1093/rheumatology/keaa541
06
Rutherford, M. A., Scott, J., Karabayas, M., Antonelou, M., Gopaluni, S., Gray, D., …Basu, N. (2021). Risk factors for severe outcomes in patients with systemic vasculitis& COVID‐19: a bi‐national registry‐based cohort study. Arthritis &Rheumatology, art.41728. https://doi.org/10.1002/art.41728
07
Trivioli, G., Gopaluni, S., Urban, M. L., Gianfreda, D., Cassia, M. A., Vercelloni, P.G., … Vaglio, A. (2021). Slowly progressive anti-neutrophil cytoplasmic antibodyassociatedrenal vasculitis: clinico-pathological characterization and outcome. ClinicalKidney Journal, 14(1), 332–340. https://doi.org/10.1093/ckj/sfaa139Rutherford, M. A., Scott, J., Karabayas, M., Antonelou, M., Gopaluni, S., Gray, D., …Basu, N. (2021). Risk factors for severe outcomes in patients with systemic vasculitis& COVID‐19: a bi‐national registry‐based cohort study. Arthritis &Rheumatology, art.41728. https://doi.org/10.1002/art.41728(Rutherford et al., 2021)
08
Wagner J, Harrison E. M, Martinez M, Pero D, Blane B, Mayer G, Leierer J,Gopaluni S, Holmes M A, Parkhill J, Peacock S J, Jayne D R, Kronbichler A (2019).The composition and functional protein subsystems of the human nasal microbiome ingranulomatosis with polyangiitis : a pilot study. Microbiome (2019) 7:137https://doi.org/10.1186/s40168-019-0753-z
09
Evaluation of PR3-ANCA Status After Rituximab for ANCA-Associated Vasculitis.McClure ME, Wason J, Gopaluni S, Tieu J, Smith RM, Jayne DR, Jones RB. J ClinRheumatol. 2019 Mar 20. doi: 10.1097/RHU.0000000000001030.
10
A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasmantibody-associated vasculitis. Pepper RJ, McAdoo SP, Moran SM, Kelly D, Scott J,Hamour S, Burns A, Griffith M, Galliford J, Levy JB, Cairns TD, Gopaluni S, JonesRB, Jayne D, Little MA, Pusey CD, Salama AD. Rheumatology (Oxford). 2019 Feb1;58(2):260-268. doi: 10.1093/rheumatology/key288.
11
Effect of Disease Activity at Three and Six Months After Diagnosis on Long-TermOutcomes in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Gopaluni S,Flossmann O, Little MA, O'Hara P, Bekker P, Jayne D; European Vasculitis Society.Arthritis Rheumatol. 2019 May;71(5):784-791. doi: 10.1002/art.40776. Epub 2019 Mar28.
12
B cell therapy in ANCA-associated vasculitis: current and emerging treatment options.McClure M, Gopaluni S, Jayne D, Jones R. Nat Rev Rheumatol. 2018 Oct;14(10):580-591. doi: 10.1038/s41584-018-0065-x. Epub 2018 Aug 14. Review.
13
A retrospective study comparing the phenotype and outcomes of patients withpolyarteritis nodosa between UK and Turkish cohorts. Karadag O, Erden A, BilginerY, Gopaluni S, Sari A, Armagan B, Ertenli I, Ozen S, Jayne D. Rheumatol Int. 2018Oct;38(10):1833-1840. doi: 10.1007/s00296-018-4122-1. Epub 2018 Aug 11.
14
Trimethoprim-sulfamethoxazole prophylaxis prevents severe/life-threatening infectionsfollowing rituximab in antineutrophil cytoplasm antibody-associated vasculitis.Kronbichler A, Kerschbaum J, Gopaluni S, Tieu J, Alberici F, Jones RB, Smith RM,Jayne DRW. Ann Rheum Dis. 2018 Oct;77(10):1440-1447. doi: 10.1136/annrheumdis-2017-212861. Epub 2018 Jun 27.
15
McAdoo, S. P., Medjeral-Thomas, N., Gopaluni, S., Tanna, A., Mansfield, N.,Galliford, J., Griffith, M., et al. (2018). Long-term follow-up of a combined rituximaband cyclophosphamide regimen in renal anti-neutrophil cytoplasm antibody-associatedvasculitis.. Nephrology, dialysis, transplantation : official publication of the EuropeanDialysis and Transplant Association - European Renal Association, 2018, 33 (5), 899.https://doi.org/10.1093/ndt/gfy075
16
Gopaluni, S., Smith, R. M., Lewin, M., McAlear, C. A., Mynard, K., Jones, R. B.,Jayne, D. R. W. (2017). Rituximab versus azathioprine as therapy for maintenance ofremission for anti-neutrophil cytoplasm antibody-associated vasculitis (RITAZAREM):study protocol for a randomized controlled trial. Trials, 18(1), 112.http://doi.org/10.1186/s13063-017-1857-zGopaluni, S., Sherif, M., & Ahmadouk, N. A. 2016. Cochrane systematic review:Interventions for chronic kidney disease-associated restless legs syndrome. CochraneDatabase of Systematic Reviews. doi: 10.1002/ 14651858. CD010690.pub2
17
Gopaluni, S., & Jayne, D. (2016). Clinical Trials in Vasculitis. Current TreatmentOptions in Rheumatology, 2(2), 161–177. doi:10.1007/s40674-016-0045-8
18
Gopaluni, S. and Jayne, D. 2015. Immune Vasculitis. eLS. 1–8. DOI:10.1002/9780470015902.a0002150.pub3
19
Hindocha, S., Gopaluni, S., Collins, G. P., & Shenbagaraman, P. (2015). Focalsegmental glomerulosclerosis in a patient with mantle cell lymphoma. BMJ CaseReports, 2015. doi:10.1136/bcr-2015-211765
20
Gopaluni, S., Gibson, M., & Mohteshamzadeh, M. (2014). An unusual case of familialcystic kidney disease. Clinical Kidney Journal, 7(5), 484–485. doi:10.1093/ckj/sfu075
21
Gopaluni, S., Sherif, M., & Ahmadouk, N. A. (2013). Protocol- Interventions forchronic kidney disease-associated restless legs syndrome. Cochrane Database ofSystematic Reviews. doi:10.1002/14651858.CD010690.
22
Ball MJ, Gopaluni S, Mathavakkannan S, Brian M, and Farrington K. Animmunocompromised dialysis patient with skin and bone lesions. NDT Plus 2010 0:sfq010v1-sfq010; doi:10.1093/ndtplus/sfq010
23
S Gopaluni, S Lines, AJP Lewington, Acute kidney injury in the critically ill patient,Current Anaesthesia & Critical Care 21 (2), 60-64, April 2010
24
Seerapani Gopaluni, Aadil Shaukat, Martin Gray, Roshni Gokhale and M Al-BustamiPremature myocardial infarction presenting with acuacutete pulmonary embolism: acase report. Journal of Medical Case Reports 2009, 3:8786
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